Use of toxicokinetic data in bioaccumulation assessment
نویسندگان
چکیده
منابع مشابه
Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in Caenorhabditis elegans
Elucidating the relationships between the toxicity-based-toxicokinetic (TBTK)/toxicodynamic (TD) properties of engineered nanomaterials and their nanotoxicity is crucial for human health-risk analysis. Zerovalent iron (Fe0) nanoparticles (NPs) are one of the most prominent NPs applied in remediating contaminated soils and groundwater. However, there are concerns that Fe0NP application contribut...
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چکیده ندارد.
15 صفحه اولToxicokinetic modeling and its applications in chemical risk assessment.
In recent years physiologically based pharmacokinetic (PBPK) modeling has found frequent application in risk assessments where PBPK models serve as important adjuncts to studies on modes of action of xenobiotics. In this regard, studies on mode of action provide insight into both the sites/mechanisms of action and the form of the xenobiotic associated with toxic responses. Validated PBPK models...
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ژورنال
عنوان ژورنال: Toxicology Letters
سال: 2016
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2016.06.1813